Synthesis of (R)-(-)-mandelic Acid by Hydrolysis of (R)-(-)-mandelic Acid Ethyl Ester by Bacillus Cereus CGMCC No.12336
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چکیده
منابع مشابه
Synthesis and Antimycobacterial Activity of Novel Mandelic Acid Derived Diamide
Introduction Increasing drug resistance and poor activity of existing therapies towards the latent stage of Mycobacterium tuberculosis infection has produced a clear need to develop novel therapeutics to treat tuberculosis [1]. Thus fast-acting drugs with novel mechanisms of action that are not cross resistant to existing drugs are being sought actively. Wilkinson and coworkers first reported t...
متن کاملStereo-selective conversion of mandelonitrile to (R)-(−)-mandelic acid using immobilized cells of recombinant Escherichia coli
Immobilized cells of a recombinant Escherichia coli expressing nitrilase from Pseudomonas putida were used to catalyze the hydrolysis of mandelonitrile (2hydroxy-2-phenylacetonitrile) to (R)-(-)-mandelic acid. The cells had been immobilized by entrapment in an alginate matrix. Conditions for the hydrolysis reaction were optimized in shake flasks and in a packed bed reactor. In shake flasks the ...
متن کاملUrinary vanillyl-mandelic acid (VMA) excretion by chronically anaemic children.
Hypoxia has been regarded as one of the many factors stimulating augmented catecholamine biosynthesis (Vogt, 1960). Plasma levels of epinephrine and norepinephrine were found to be increased in newborns with the respiratory distress syndrome or placental insufficiency (Cheek, Malinek, and Fraillon, 1963). Infants with severe heart failure eliminate in the urine twice as much metanephrine, norme...
متن کاملSummary of Mandelic Acid for the Improvement of Skin Conditions
Mandelic acid has been used in medicine for many years as a urinary antiseptic. Methenamine mandelate (Mandelamine®, Parke-Davis, Morris Plains, NJ) has the urinary antiseptic action of both methenamine and mandelic acid. In concentrations of 35g to 50g/100L of urine, it inhibits Staphylococcus aureus, bacillus proteus, escher ichia col i , and aerobacter aerogenes. Chemically, mandelic acid ha...
متن کاملMetabolic engineering of the L-phenylalanine pathway in Escherichia coli for the production of S- or R-mandelic acid
BACKGROUND Mandelic acid (MA), an important component in pharmaceutical syntheses, is currently produced exclusively via petrochemical processes. Growing concerns over the environment and fossil energy costs have inspired a quest to develop alternative routes to MA using renewable resources. Herein we report the first direct route to optically pure MA from glucose via genetic modification of th...
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ژورنال
عنوان ژورنال: DEStech Transactions on Biology and Health
سال: 2018
ISSN: 2575-8918
DOI: 10.12783/dtbh/icmsb2017/17941